The blood pressure-lowering effect of Cialis is usually mild and temporary, and it is generally not significant enough to cause problems in people without pre-existing low blood pressure. However, it can have a more pronounced effect in certain situations, especially when combined with other medications that lower blood pressure. Cialis and blood pressure , but the effect is usually mild and well-tolerated for most people. However, it can cause a more pronounced drop in blood pressure when taken with certain medications (such as nitrates) or in individuals with pre-existing low blood pressure. However, everyone's body responds differently, so it's important to monitor for any potential side effects.